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Artículos Científicos RSS JASN

High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD

High levels of proenkephalin-A (pro-ENK) have been...

Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function

The cardiac natriuretic peptides (NPs), atrial NP and B-...

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI

AKI is histologically characterized by necrotic cell...

Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion

We recently described a novel thiazide–sensitive...

Wnt7b Signaling from the Ureteric Bud Epithelium Regulates Medullary Capillary Development

The renal vasculature is integral to the physiologic...

Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion

Patients with cystic fibrosis have an increased...

Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes

Klotho is a type-1 membrane protein predominantly...

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

Renal proximal tubular cells constantly recycle...

The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane

Phosphoinositides, a family of phosphorylated...

Corticosteroids in IgA Nephropathy: Lessons from Recent Studies

IgA nephropathy (IgAN) is a common chronic glomerular...

Does Renal Repair Recapitulate Kidney Development?

Over a decade ago, it was proposed that the regulation...

CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN

Observations in patients with ANCA-associated vasculitis...

Exome Sequencing Discerns Syndromes in Patients from Consanguineous Families with Congenital Anomalies of the Kidneys and Urinary Tract

Congenital anomalies of the kidneys and urinary tract (...

Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation

CKD associates with systemic inflammation, but the...

MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2

The renal proximal tubule reabsorbs 90% of the filtered...

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