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Candidate Surrogate End Points for ESRD after AKI

AKI, a frequently transient condition, is not accepted...

Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD

Kidney disease leads to clinically relevant disturbances...

Predicted Mutation Strength of Nontruncating PKD1 Mutations Aids Genotype-Phenotype Correlations in Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD)...

Rare Variants in the Complement Factor H-Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy

A recent genome–wide association study of IgA...

Urinary Soluble CD163 in Active Renal Vasculitis

A specific biomarker that can separate active renal...

Role of Receptor Protein Tyrosine Phosphatase {gamma} in Sensing Extracellular CO2 and HCO3-

Regulation of blood pH—critical for virtually every...

Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an {alpha}-Klotho-Deficient Model

Inorganic phosphate (Pi) has been implicated in the...

Serum Glucocorticoid-Regulated Kinase 1 Blocks CKD-Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3

Muscle proteolysis in CKD is stimulated when the...

Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells

The mechanisms by which the glomerular filtration...

Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects against Hemoglobin-Mediated Kidney Injury

Urinary hepcidin may have protective effects against AKI...

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy

Mitochondrial fission has been linked to the...

IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition

IgA1 mesangial deposition is the hallmark of IgA...

Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells

In humans, nephrogenesis is completed prenatally, with...

TRPC6 G757D Loss-of-Function Mutation Associates with FSGS

FSGS is a CKD with heavy proteinuria that eventually...

Glucocorticoid-Regulated Kinase: Linking Azotemia and Muscle Wasting in CKD

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