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Potassium and Its Discontents: New Insight, New Treatments

Hyperkalemia is common in patients with impaired kidney...

The Polycystin-1, Lipoxygenase, and {alpha}-Toxin Domain Regulates Polycystin-1 Trafficking

Mutations in polycystin-1 (PC1) give rise to autosomal...

Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth

The molecular mechanisms underlying renal growth and...

Phosphoinositide 3-Kinase-C2{alpha} Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

Signaling from the primary cilium regulates kidney...

Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes

Podocytes are terminally differentiated epithelial cells...

HANAC Syndrome Col4a1 Mutation Causes Neonate Glomerular Hyperpermeability and Adult Glomerulocystic Kidney Disease

Hereditary angiopathy, nephropathy, aneurysms, and...

Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1

Nephrotic syndrome is a CKD defined by proteinuria with...

Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor

Nephrin belongs to a family of highly conserved proteins...

Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury

The plasticity of dendritic cells (DCs) permits...

Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1-Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism

Secondary hyperparathyroidism is characterized by...

Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease

cAMP stimulates cell proliferation and Cl-...

Double-Negative {alpha}{beta} T Cells Are Early Responders to AKI and Are Found in Human Kidney

Ischemia-reperfusion injury (IRI) is a major cause of...

Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD

Traditional histologic methods are limited in their...

Nephrin Trafficking beyond the Kidney--Role in Glucose-Stimulated Insulin Secretion in {beta} Cells

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Podocyte Expression of B7-1/CD80: Is it a Reliable Biomarker for the Treatment of Proteinuric Kidney Diseases with Abatacept?

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