We appreciate the comments from Lin et al1 regarding our recent article2 in AJKD. We acknowledge that the CRIC Study provides a restricted annual assessment of analgesic exposure, which could lead to under-reporting of analgesic use, but the bias applies to all analgesics and confers nonspecific attenuation of our findings toward the null. We concluded that the association of NSAIDs with outcomes was variable and needs clarification. Opioids had a stronger association with poor outcomes.