Treatment Outcomes in Syndrome of Inappropriate Antidiuresis: Improvements in Hyponatremia May Reflect Successful Treatment or Resolution of the Underlying Cause
In a recent randomized controlled study, Krisanapan et al1 demonstrated that the addition of furosemide, with or without sodium chloride, provided no additional benefit to fluid restriction alone in correcting plasma sodium in patients with syndrome of inappropriate antidiuresis (SIAD).1 These prospective data in patients with a robust biochemical diagnosis of SIAD are a welcome addition to the literature on SIAD treatment, an area that is deficient in prospective randomized studies of first-line treatments.
