In their editorial, Fishbane and Hirsh1 discuss associations between systemic inflammation and anemia in patients with coronavirus disease 2019 (COVID-19). This relationship, putatively attributed to hepcidin effects on iron availability, limits erythropoietin (EPO) efficacy. Despite this, the authors theorize that synergism between severe COVID-19 and erythropoiesis-stimulating agent use may produce dangerous thrombosis risks. They propose reduced hemoglobin level targets in maintenance dialysis patients with COVID-19 despite an association between anemia and more severe COVID-19.