Interventions for Preventing Bone Disease Following Kidney Transplantation: Is There Evidence for Specific Therapy?
Among patients with chronic kidney disease (CKD), disorders of mineral metabolism are a major cause of morbidity. As the prevalence of kidney disease and rate of kidney transplantation both increase, there is a growing prevalence of CKD–mineral and bone disease (CKD-MBD) among transplant recipients. Before kidney transplantation, CKD-MBD affects almost all patients with CKD. Posttransplantation, many patients still have some degree of reduced kidney function, as well as transplant-associated disturbances in mineral metabolism.