Peripheral Artery Disease in CKD: Anatomically Peripheral But Clinically Central

Lower-extremity peripheral artery disease (PAD) affects approximately 10 million adults in the United States1 and more than 200 million adults throughout the world.2 Its global prevalence has increased by 24% from 2000 to 2010.2 PAD is associated with an increased risk for other cardiovascular diseases such as myocardial infarction and stroke, reduces quality of life, and is a leading cause of nontraumatic leg amputation. A recent study showed that patients with PAD alone had a poorer prognosis than those with myocardial infarction and/or stroke without PAD.