Continuous renal replacement therapy (CRRT) is often used for solute, acid-base, and volume management in hemodynamically compromised critically ill patients with acute kidney injury, and it is estimated that ~5% of intensive care unit patients require CRRT.1-3 Several questions regarding the practice of CRRT that are the subject of ongoing research include optimal timing of CRRT initiation and discontinuation,4,5 optimal CRRT modality, and the role of high-volume hemofiltration6,7 and hemoadsorption8,9 in sepsis.