Rood et al1 discussed genetic counseling of patients with the R229Q variant of NPHS2, the gene encoding podocin, in steroid-resistant nephrotic syndrome (SRNS). Our results2 are partly misinterpreted because the authors present all exon 7 to 8 mutations as pathogenic in combination with R229Q. We classified the mutations based on their location (exons 1-6 vs. exons 7-8) only to show that R229Q is typically associated with exons 7-8 mutations in affected individuals and thus to suggest the mutation-dependent pathogenicity of R229Q.