The theme of the 2017 Frank M. Norfleet Forum for Advancement of Health, held on March 24, 2017, was “African Americans and Kidney Disease in the 21st Century.” The articles in this journal supplement are based on the presentations during the forum; both the forum and costs for publication of this journal supplement were sponsored by the Frank M. Norfleet Forum for Advancement of Health, the Community Foundation of Greater Memphis, and the University of Tennessee Health Science Center.