Chronic kidney disease (CKD) affects approximately 1 in 10 adults worldwide.1 Although progression to end-stage renal disease (ESRD) is expected in only 3% of the CKD population, it is associated with major health burdens.1 Knowledge of the constellation of features that put a person at high risk for ESRD can influence decisions around screening, prognostication, and even treatment. Many of these risk factors are well recognized, including older age, hypertension, diabetes, cardiovascular disease, and family history of kidney disease.