A 13-year-old girl of Nigerian and German descent underwent deceased donor kidney transplantation for stage 5 chronic kidney disease due to focal segmental glomerular sclerosis (FSGS). Initial presentation was with edema and oliguria at 7 years of age with no response to prednisone and cyclosporine A (CsA) treatment. Sanger sequencing of the NPHS2 and WT1 genes did not reveal alterations. After 2 years, peritoneal dialysis therapy was initiated. The patient was anuric. Native kidneys were left in situ.