Phosphate Binders: The Evidence Gap Persists

Several observational studies have reported associations of hyperphosphatemia with increased risks for cardiovascular events and mortality in individuals with chronic kidney disease (CKD).1 The KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guideline on the management of CKD−mineral and bone disorder recommends keeping serum phosphorus levels within the normal range for patients with CKD stages 3 to 5, including those receiving dialysis who are using dietary measures or certain medications, so-called phosphate binders.