Cortical necrosis commonly manifests clinically as a rapid loss of glomerular filtration rate, often with oliguria, granular casts, and low-level proteinuria. Cortical necrosis may occur at any age. Causes include complications of vascular anastomosis in the transplanted kidney. In the native kidney, it occurs after thrombosis of interlobular or larger arteries, massive cholesterol emboli, septic abortion, or other catastrophic obstetrical complications (including eclampsia), and in the neonate, it occurs as complications of sepsis and placental hemorrhage.