Chronic kidney disease (CKD) associated with hypertension disproportionately affects African Americans, and occurs at younger age (as young as 20s) and with faster progression than in whites. Men are affected more than women. Patients develop progressive proteinuria that is related to the severity of hypertension, and may even have nephrotic range proteinuria. Hypertension-associated CKD accounts for approximately 25% of patients reaching end-stage kidney disease. Intensive therapy with antihypertensive drugs, including renin-angiotensin blockade, slows progression.