Galectin-3 and soluble ST2 (sST2), novel biomarkers of cardiovascular stress, predict cardiovascular events and death.1,2 Relationships with progression of kidney disease are less certain. Galectin-3 is a β-galactoside–binding lectin expressed by activated macrophages that induces cardiac fibroblasts to deposit type I collagen, which contributes to myocardial fibrosis and adverse remodeling.3 sST2, a member of the IL-1 receptor family, is thought to neutralize the beneficial effects of IL-33,4 which has antihypertrophic effects in cardiomyocytes and reduces myocardial fibrosis.