Authors: Betonico GN, Abudd-Filho M, Goloni-Bertollo EM, Pavarino-Bertelli E
Since the Human Genome Project, the evaluation of the effectiveness and safety of some medications has become partially connected to innate metabolic patterns. Thus, genes that encode receptors and enzymes could play different roles in metabolism, according to their polymorphisms. Especially in organ transplantation, some of the available medications used in immunosuppressive therapy have a narrow therapeutic index, affecting the individual response to these drugs. This review focuses on the polymorphism of genes that encode enzymes of the uridino-glucuronosyltransferase (UGT) family, responsible for the bioavailability of mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), used as an immu...