Conclusion: Our results suggest that GSPEs hold substantial promise for the treatment of DN. GSPEs can decrease proteinuria and attenuate the progression of nephropathy in diabetic rats. Renoprotective effects of GSPE correlated with suppression of AGEs, down-regulating expression of CTGF and up-regulating the expression of BMP-7.
PMID: 18949727 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)