Effect of phlorizin on sglt2 expression in the kidney of diabetic rats.

Conclusions: In conclusion, SGLT2 inhibition prevented the development of hypertension in diabetic rats as well as hyperglycemia, suggesting a hypertensive mechanism associated with SGLT2 activity and the likelihood that increased SGLT2 expression may be associated with progression of diabetic renal complications.
PMID: 20349407 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)