Conclusions: These results suggest that UUO-induced tubulointerstitial fibrosis can be effectively attenuated by GPs application. GPs-mediated down-regulation of TGF-ss1 and CTGF and up-regulation of Smad7 are essential for their effects of antifibrogenesis.
PMID: 20540031 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)