Cyclosporine A causes maturation failure in embryonic-type glomeruli persisting after birth.

Conclusion: Our findings indicate a need for caution in CyA therapy for patients with NS, even for a relatively short course of administration, because some patients may have embryonic-type glomeruli or immature arterioles that predispose them to CyA nephropathy.
PMID: 20954140 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)