High-sodium diet promotes a profibrogenic reaction in normal rat kidneys: effects of Tempol administration.

Conclusion: The results showed that a high NaCl diet is able to produce a renal profibrotic response also in normal rats, which could be associated with oxidative stress rather than intrarenal Ang II expression.
PMID: 20954139 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)