L-Carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues.
Conclusions: l-Carnitine prevents the development of IFO-induced Fanconi syndrome by increasing intracellular carnitine content and intramitochondrial CoA-SH, with the consequent improvement in mitochondrial oxidative phosphorylation and energy production, as well as its ability to decrease oxidative stress.
PMID: 21404227 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)