Increased apoptosis and expression of FasL, Bax and caspase-3 in human lupus nephritis class II and IV.

Conclusions: Increased apoptosis and the expression of FasL, Bax and caspase-3 in human LN suggest that apoptosis might be induced through pathways of these proteins in the pathogenesis process and play an important role in LN progression through Bax and caspase-3, but not FasL.
PMID: 21725926 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)