Administration of vitamin E and losartan as prophylaxes in cisplatin-induced nephrotoxicity model in rats.
Conclusions: Although vitamin E or losartan as prophylaxes demonstrated some protective effects, the combination of losartan and vitamin E did not protect against CDDP-induced nephrotoxicity, for unknown reasons which may relate to pharmacokinetic or pharmacodynamic drug interactions.
PMID: 21928232 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)