Conclusions: Overall there was agreement in sitagliptin dose using MDRD and CG equations. Discrepancies resulted in underestimation of sitagliptin dose at eCLCr above 50 ml/min and overestimation at lower eCLCr. Clinical implications are the potential for excessive dosing of sitagliptin and other agents with similar dose stratification by eCLCr in individuals with kidney dysfunction.
PMID: 21928236 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)