Authors: Gentile G, Strippoli GF
Abstract
Hypertension is the leading cause of death worldwide and is responsible for a significantly increased burden of cardiovascular events and progression to end-stage kidney disease in patients with chronic kidney disease (CKD). The fundamentals of therapeutics in patients with hypertension and CKD are both the use of specific renal protecting agents and the achievement of tight blood pressure control - i.e., blood pressure values below 130/80 mm Hg. When the evidence underpinning a "tight blood pressure target control" recommendation is analyzed, hypertension guidelines appear to be largely extrapolating to people with CKD the key findings of large trials conducted in the general population and other high cardiovascular risk populations, while...