Clinical significance of IgM and C1q deposition in the mesangium in pediatric idiopathic nephrotic syndrome.

Conclusions: Our results indicate that, regardless of the histological pattern (minimal change disease, focal segmental glomerulosclerosis or diffuse mesangial hypercellularity), children with IgM+ and/or C1q+ INS have good responses to CyA. IgM+ and/or C1q+ may be markers of the initial disease severity of INS.
PMID: 22641570 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)