Authors: Stallone G, Infante B, Grandaliano G
Abstract
Acute kidney injury (AKI) is associated with significant morbidity, mortality, and health care costs. In spite of significant advances in health-care technology over the past few years, the incidence of AKI appears to be increasing over time. Elderly subjects represent the segment of the general population in which the incidence of AKI has been increasing the most. AKI is usually diagnosed by an abrupt change in serum creatinine concentration. The rate and magnitude of the rise in serum creatinine may be blunted in the elderly because of the reduced muscle mass and, thus, serum creatinine is not an ideal biomarker for AKI in this population. In the last few years, several studies have suggested new biomarkers that may help the ...