Conclusions: These findings suggested that TRPC6 and CaN were up-regulated on mRNA and protein levels in adriamycin-induced rats. FK506 had a therapeutic effect on the progression of proteinuria and renal damage by down-regulating of TRPC6 and CaN in the renal tissues.
PMID: 22865594 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)