We thank Dr Sahutoglu for his letter.1 Pregnant women with increased levels of antiangiogenic factors, such as sFlt1, are at risk of pre-eclampsia/HELLP (hemolysis, elevated liver enzymes, and low platelets). sFlt1 has been shown to cause pre-eclampsia in mice, with glomerular endotheliosis.2 Most, if not all, kidney biopsies from pre-eclamptic patients show glomerular endotheliosis, while thrombosis is rare.3 sFlt1 levels fall after delivery, with rapid clinical improvement.