Obesity is a chronic disease the requires lifelong care. The prevalence of obesity has surpassed diabetes and hypertension and is now the most common risk factor for chronic kidney disease (CKD) and its progression. Excess weight not only increases CKD risk but also heightens the risk for heart failure, sleep apnea, steatotic liver disease, osteoarthritis, and a myriad of other chronic conditions. The interplay between obesity, kidney, cardiovascular, and metabolic health has been termed the cardiovascular-kidney-metabolic syndrome.