Chronic kidney disease (CKD) and peripheral artery disease (PAD) are highly prevalent conditions associated with morbidity, mortality, and healthcare costs, particularly when they coexist. Despite advances in pharmacological and interventional therapies, patients with both CKD and PAD have rapid functional decline, higher hospitalization rates and poor cardiovascular outcomes. In populations with either CKD or PAD alone, exercise training has been shown to improve cardiorespiratory fitness, muscle strength, physical function, and quality of life and is strongly recommended in guidelines.