The longitudinal cohort study by Driehuis et al1 in this issue of AJKD offers an important and timely contribution to the nephrology literature by examining trajectories of experiences and health-related quality of life among informal caregivers of people receiving dialysis, comparing home-based and in-center modalities. Informal caregivers play a critical yet often invisible role in kidney care, providing practical, emotional, and logistical support that sustains patients through the demanding course of kidney failure treatment.