Association of Recurrent Atrial Fibrillation With Subsequent Kidney Function Decline in Adults Receiving Rhythm Control Therapy

Atrial fibrillation (AF) is the most common sustained arrhythmia in adults worldwide. The incidence of AF is 2-to-3-fold higher in chronic kidney disease (CKD) compared with the general population1 and is associated with a high risk of subsequent cardiovascular events. In addition, studies have found an association of AF with loss of kidney function.2-4 Possible mechanisms to explain this association include alterations in renal hemodynamics, upregulation of inflammatory pathways and microinfarcts, among others.