Immunoglobulin A nephropathy (IgAN) is the most common immune-mediated glomerular disease worldwide. Advanced understanding of the role of complement in IgAN pathogenesis has motivated the development of complement inhibition as a therapeutic strategy. Iptacopan, a complement factor B inhibitor, is the first approved complement inhibitor for IgAN. Several other complement inhibitors are being studied in Phase II/III clinical trials. How best to integrate complement inhibition into the evolving treatment paradigm for IgAN remains a challenge.