Comprehensive medication management (CMM) is the standard of care that ensures medications are individually assessed to determine that each medication is appropriate, effective for the medical condition, safe given the patient’s comorbidities and other medications, and able to be taken by the patient as intended. CMM helps improve all aspects of healthcare quality and is essential for individuals with chronic kidney disease (CKD). It specifically addresses the complexity of medication regimens in patients with multiple comorbid conditions that often lead to medication therapy problems.