When kidney function or tubular sodium handling are abnormal, excessive dietary sodium can lead to a salt-sensitive increase in blood pressure.1,2 Of people in the US who have chronic kidney disease (CKD) and hypertension, over 40% are treated but have uncontrolled hypertension.3 The inability of the kidney to handle sodium may be an early signal of kidney dysfunction4; thus, hypertension responsive to dietary sodium may be a marker of kidney dysfunction. Nevertheless, the actual mechanism whereby dietary salt influences blood pressure remains unknown.