Mitochondrial dysfunction plays a central role in chronic kidney disease (CKD) pathogenesis and progression. It is associated with inflammation, oxidative stress, and cellular senescence. In this regard, targeting the restoration of mitochondrial function could potentially delay disease progression and alleviate uremic symptoms. Notably, bioactive compounds, naturally present in food, have recently gained attention due to their potential to counteract mitochondrial dysfunction. These compounds include a diverse array of phytonutrients, such as antioxidants, vitamins and polyphenols, but also omega-3 fatty acids, that support cellular health, reduce the risk of chronic diseases, and help modulate metabolism.