As health care systems worldwide strive to expand peritoneal dialysis (PD) utilization, much of the focus has centered on increasing uptake of the modality; however, reducing discontinuation is equally important for successful PD growth and also represents a patient-centered outcome.1,2 While previous research has consistently demonstrated that male patients face elevated risks for PD discontinuation compared to their female counterparts, the underlying mechanisms driving this sex-based disparity have remained poorly understood.