Heart failure (HF) and kidney disease are intricately linked.1 Approximately 10%-30% of patients with chronic kidney disease (CKD) have HF, while ∼30%-60% of patients with HF have CKD.2 This population of patients with concurrent HF and kidney disease, which continues to grow, is at elevated risk of loss of kidney function, frequent hospitalizations, and death.3 The interplay between HF and kidney disease is complex and multifactorial. The contribution of volume overload has long been postulated as a central mechanism leading to kidney disease, both acutely and in the long term.