Symptomatic kidney stone events confer significant population-level morbidity and mortality,1 with increasing worldwide incidence and prevalence rates over the last few decades.2 A vast majority (over 80%) of human stones contain calcium, mostly in the form of calcium oxalate; however, more than 10% of analyzed stones contain a majority of calcium phosphate (CaP).3 The fraction of CaP stones is even higher in the second and third decades of life, and more so in younger women than men.3 The reasons for these demographic trends remain unclear.