Urinary tract infections (UTI) are a common infection that, if left untreated, can lead to complications such as pyelonephritis or sepsis.1 Patients with chronic kidney disease (CKD) are at increased risk of developing UTIs, particularly those patients who require long-term hemodialysis.2 In this issue of AJKD, Liyanarachi et al3 propose that some of the excess UTI risk found in patients with CKD could be associated with decreased urinary uromodulin. Uromodulin (also known as Tamm-Horsfall protein or THP) is made exclusively by the kidney and secreted apically from the thick ascending limb of the loop of Henle, where it passes through the distal tubules and makes its way into the urine.