Patients with crystalglobulinemia are usually aged 40-85 years with underlying plasma cell dyscrasia. In some cases, the increased precipitation of these crystals with cold exposure has led to use of the term cryocrystalglobulinemia. Crystalglobulin-induced nephropathy often presents with severe acute kidney injury and patients with large vessel involvement can develop kidney infarction. This condition can be life threatening and associated with crystal precipitation in the vasculature of major organs and concurrent thrombosis.