Polygenic Risk Scores for CKD Among an Ethnically Diverse Cohort of People With HIV

Chronic kidney disease (CKD) is significantly more prevalent among persons with HIV (PWH), despite the widespread implementation of antiretroviral therapy.1,2 This risk has been ascribed to both HIV-specific factors, such as prolonged viremia, lower nadir CD4 count, and use of nephrotoxic antiretroviral therapy, as well as an increasing incidence of comorbidities such as hypertension and diabetes.3 PWH of African ancestry have higher CKD risk, partially owing to the carriage of the APOL1 risk alleles.