Acute kidney injury (AKI) occurs in more than a quarter of children in the intensive care unit (ICU), with more than 10% developing severe AKI within the first 7 days of their ICU admissions.1 For both children and adults, worsening severity of AKI is associated with a stepwise increase in mortality.1,2 In addition to longer hospitalization and prolonged mechanical ventilation, AKI is increasingly recognized as a risk factor for long-term adverse outcomes such as hypertension, cardiovascular disease, and chronic kidney disease.