As recently highlighted by the American Heart Association statement on Cardiovascular-Kidney-Metabolic syndrome, people with chronic kidney disease (CKD) are at high risk of cardiovascular disease (CVD).1 Our understanding of the multiplicative effects of CKD and CVD on mortality has led to a deeper appreciation of the urgency of studying these frequently concomitant conditions, particularly in those with more advanced CKD. Previous studies have underscored sex and gender differences in CVD risk in the general population,2 but are sex and gender considerations needed in kidney and CVD clinical research?