Kidney stone disease (KSD) is one of the most prevalent and growing health care challenges, affecting people in developed and developing nations.1 Its association with comorbidities, such as chronic kidney disease, obesity, cardiovascular disease, and hyperlipidemia, imposes a long-term disease burden on individuals with KSD.2-4 To develop effective prevention and management strategies, it is essential to understand the complex etiology of KSD by considering patient-specific factors such as genetic predisposition, comorbid conditions, diet, lifestyle habits, available personal resources, and the interactions among them.