Acute kidney injury (AKI) is common in hospitalized adults and is associated with significant increases in mortality, health care costs, and the risk of developing long-term conditions such as chronic kidney disease (CKD) and end-stage kidney disease (ESKD).1 One major risk factor for AKI is being aged 65 or over;2 however, the mechanisms driving this association remain unclear. Clonal hematopoiesis of indeterminate potential (CHIP) was first described in 2015 and is defined by the presence of clonally expanded hematopoietic stem cells harboring leukemogenic variants in individuals without neoplasia.